How long does your Botox treatment take? Home » General FAQ » How long does your Botox treatment take? Our Marina Del Rey Botox treatment takes about 10 minutes. For those who prefer numbing cream beforehand, plan on an extra 20-30 minutes so that the numbing cream has time to take effect. Related Posts What is Botox? How Long After Body Contouring Do You See Results? Understanding Botox®: How Does It Work Innovative Facial