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Book NowJuvederm is FDA approved and any possible side effects are typically short in duration, lasting one week or less. Most side effects are mild to moderate, including facial redness, pain or tenderness, swelling, bruising, itching, firmness, lumps/bumps and discoloration at the injection site. As with all other skin injection procedures, there is a risk of infection. Ask your doctor if you have questions about Juvederm side effects.