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Book NowThe difference between Restylane and Restylane Lyft is that the molecule in Restylane Lyft is about 4x larger, so it takes the body longer to break the product down. Restylane Lyft is also placed deeper in the dermis and has the ability to fill in folds with less material. Restylane typically lasts 6-8 months, whereas Restylane Lyft filler treatment typically last 6-12 months.